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ISA 2004 - "Error Code 64: Host not available" when accessing a website.

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When our users try to access the website http://my.inex24.com/ they get the following error message:

Network Access Message: The page cannot be displayed

Technical Information (for support personnel)
Error Code 64: Host not available
Background: The gateway or proxy server lost connection to the Web server.
Date: 9/11/2014 10:43:45 AM
Server: InternalISAServer
Source: Remote server

This apparently started happening about two weeks ago. (Needless to say, we did not have any scheduled changes, although we did have an issue with SCCM around that time)
We don't have any compression policies set (in Define HTTP Compression Preferences), this seems to be the most common source of these problems...

The site inex24.com can be accessed fine though.

When viewing the live logs on the ISA Server, I see these connection attempts:

1)
Denied Connection InternalISAServer 11/09/2014 11:43:45 
Log type: Web Proxy (Forward) 
Status: 12209 The ISA Server requires authorization to fulfil the request. Access to the Web Proxy service is denied.  
Rule: CORP 
Source: Internal ( 10.201.28.82:0) 
Destination: External ( 10.201.10.167:8080) 
Request: GET http://my.inex24.com/ 
Filter information: Req ID: 5bbb50a5; Compression:None 
Protocol: http 
User: anonymous 

2)
Failed Connection Attempt InternalISAServer 11/09/2014 11:43:45 
Log type: Web Proxy (Forward) 
Status: 5 Access is denied.  
Rule: CORP 
Source: Internal ( 10.201.28.82:0) 
Destination: External ( 10.201.10.167:8080) 
Request: GET http://my.inex24.com/ 
Filter information: Req ID: 5bbb50a6; Compression:None 
Protocol: http 
User: anonymous 

4)
Failed Connection Attempt InternalISAServer 11/09/2014 11:43:45 
Log type: Web Proxy (Forward) 
Status: 64 The specified network name is no longer available.  
Rule: CORP 
Source: Internal ( 10.201.28.82:0) 
Destination: External ( 195.30.116.8:80) 
Request: GET http://my.inex24.com/ 
Filter information: Req ID: 5bbb50a7; Compression:None 
Protocol: http 
User: Domain\ME 

5)
Failed Connection Attempt InternalISAServer 11/09/2014 11:43:46 
Log type: Web Proxy (Forward) 
Status: 64 The specified network name is no longer available.  
Rule: CORP 
Source: Internal ( 10.201.28.82:0) 
Destination: External ( 195.30.116.8:80) 
Request: GET http://my.inex24.com/favicon.ico 
Filter information: Req ID: 5bbb50a8; Compression:None 
Protocol: http 
User: Domain\ME 


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