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TMG 2010 Spam and AV filtering

I've read a lot online about how to configure spam and AV filtering in TMG 2010 and the settings seem very flexible and powerful. What I'm not so sure about is how to effectively set the options - for example there isn't much information on 'typical' settings to use - i.e. which file types to block, spam keywords for content filtering (on that matter is there a way to enter more than 1 word at a time?), Sender Reputation or whether enabling Sender ID is practical?

 Do most people just guess these settings and tweak over time?


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