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Outlook Anywhere no longer working - Error Code 64

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Environment: Exchange 2007 Sp3 single server with all roles.  Outlook Anywhere, ActiveSync, EWS, and OWA are published using ISA 2006.  ISA 2006 is a single NIC setup and is only functioning as a reverse proxy for Exchange and SharePoint.

Issue:

Outlook anywhere has stopped working in my environment.  Not sure when, but I found this out today.

Basically, when I open Outlook outside of my network, I am prompted for credentials and after entering my credentials Outlook hangs for a short while and then dispays "Microsoft Exchange is Unavailable - retry, work offline or cancel".  On the ISA server side I see several "Failed Connection Attempts - (LDAP) username RPC_IN_DATA http://email.domain.com/rpc/rpcproxy.dll?internalemailserver.local:6004 

The RPC_IN_DATA URL also has another failed entry with a different internal server name for one of my AD servers EXamplehttp://email.domain.com/rpc/rpcproxy.dll?internalADserver.local:6004 

In addition there is an "Allowed Connection" entry for RPC_OUT_DATA forhttp://email.domain.com/rpc/rpcproxy.dll?internalADserver.local:6004 

If I open the url: https://email.domain.com/rpc/rpcproxy.dll I receive the ISA logon page.  After logging on I receive the following:

Technical Information (for support personnel)

  • Error Code 64: Host not available
  • Background: The connection to the Web server was lost.

I am really at a loss here.  As I stated I am not entirely sure when this issue occurred.  I recently published EWS through ISA by adding the path /EWS/* to the Outlook Anywhere rule.  I did create an EWS external URL on the Exchange server.  Other than this I am not aware of any other changes.

Can you please offer assistance.



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