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10 second delay when loading webpages

Hi All, thanks in advance for reading.

I'm in the process of moving our web users off our old ISA 2006 perimeter firewall and onto our TMG 2010 firewall.  I am facing an issue where connection attempts to some websites (not just the first time web is used) have a 10 second delay before they connect.  

We have a fairly standard multihomed setup.  I've been through the network adapter best practices and amended the binding order to make sure the internal network is highest, but to no avail.  I've also made sure that I only have a DNS server against the internal adapter and the DNS server specified can correctly resolve external DNS entries.

I am using IE9 for this, with the proxy defined by hostname and the "automatically detect scripts" checkbox unchecked.  For testing, I've created a rule which allows my computer out without any authentication and removed the proxy settings in my IE.  This results in a bit quicker access, but still not instantaneous.  Does this maybe rule out the web proxy?

Forgot to mention, TMG version is 7.0.9193.500.

Any ideas?


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